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Description
B7-H3/CD276 His Tag Protein, HumanProduct Specification Species Human Synonyms B7 H3, CD276; B7H3, B7 H3, CD276 antigen, CD276 molecule, CD276, B7H34Ig B7 H3, B7 H3B7 homolog 3, Costimulatory molecule Accession Q5ZPR3 2 Amino Acid Sequence Leu29 Pro245, with C terminal His Tag Expression System HEK293 Molecular Weight 38 48 kDa(Reducing ) Purity 95%, by SDS PAGE under reducing conditions Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder
Product Specification
| Species | Human |
| Synonyms | B7-H3, CD276;B7H3, B7-H3, CD276 antigen, CD276 molecule, CD276, B7H34Ig-B7-H3, B7-H3B7 homolog 3, Costimulatory molecule |
| Accession | Q5ZPR3-2 |
| Amino Acid Sequence | Leu29-Pro245, with C-terminal His Tag |
| Expression System | HEK293 |
| Molecular Weight | 38-48 kDa(Reducing ) |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS pH7.2, 5% trehalose |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
B7 homolog 3 (B7-H3, CD276) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. B7-H3 protein contains two extracellular Ig-like V-type domains and two IgG-like C2-type domains, a transmembrane domain, and a short intracellular domain . Early research examining the biological process of B7-H3 suggested that B7-H3 is a positive regulator of T cell response . Subsequent research studies indicated that B7-H3 is a negative regulator of T cell response, and that the protein inhibits T cell proliferation . One possibility is that B7-H3 interacts with two distinct sets of receptors, resulting in seemingly opposite biological outcomes . B7-H3 is expressed by antigen presenting cells, activated T cells, and a few normal tissues, including placenta and prostate . Expression of B7-H3 is seen in several cancer types, including prostate, breast, colon, lung, and gastric cancers, and in endothelial cells from tumor associated vasculature.
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