SKU: 50433947049

IL-12 R beta 1 Fc Chimera Protein, Human

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Description

IL-12 R beta 1 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms IL 12 R beta 1, IL12RB1, CD212, IL12R, IL12RB, IL 12RB1 Accession P42701 Amino Acid Sequence Cys24 Glu540, with C hIgG Fc Expression System CHO Molecular Weight 95 110kDa (Reducing) Purity 95% by SDS PAGE & >95% by SEC HPLC Endotoxin <0. 1EU g Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, PH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water

Product Specification


Species Human
Synonyms IL-12 R beta 1, IL12RB1, CD212, IL12R, IL12RB, IL-12RB1
Accession P42701
Amino Acid Sequence

Cys24-Glu540, with C-hIgG Fc
Expression System CHO
Molecular Weight

95-110kDa (Reducing)
Purity ＞95% by SDS-PAGE & >95% by SEC-HPLC
Endotoxin <0.1EU/μg
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, 5% trehalose, PH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.
Reference

1. Pérez-Martínez L, Romero L, Verdugo-Sivianes EM, Muñoz-Galván S, Rubio-Mediavilla S, Amiama-Roig A, Carnero A, Blanco JR. Role of maraviroc and/or rapamycin in the liver of IL10 KO mice with frailty syndrome. PLoS One. 2024 Jan 10;19(1): e0286201. l. (2008) Nat.
2. Chan BC, Li P, Tsang MS, Sung JC, Kwong KW, Zheng T, Hon SS, Lau CP, Ho RC, Chen F, Lau CB, Leung PC, Wong CK. Adjuvant activities of immunostimulating natural products: Astragalus membranaceus (Fisch.) Bge. and Coriolus versicolor in BNT162b2 vaccination against COVID-19 infection. J Leukoc Biol. 2024 Jan 5;115(1):177-189.

Background

IL-12 R beta 1 (Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

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Exchange/Return Notes
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SKU: 50433947049

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dr
Grantham, US
★★★★★ 4
Sturdy. Built to last. It solves all the problems my old organizer had. Very satisfied.
Review for ARTLEO Kitchen Sink Caddy with Super Water Absorbent Diatomite Stone Sink Tray, Fast Drying Sink Organizer with High Dish Brush Holder Sponge Holder for Kitchen Sink, Stainless Steel This appears to be a sturdy organizer of stainless steel painted with a good amount of black protective paint. I ordered it to replace an inferior organizer of the same material (made by a different company altogether). This one solves the problems I had with my previous organizer which had begun to rust and break apart after six months of use. The narrow steel bars on the bottom shelf of this new organizer are supported by wider steel flats in the frame that will prevent them from breaking off the frame. (My old organizer bars broke because they were barely welded onto the frame and the repeated "pushing down" of my soap pump-bottle eventually broke them apart from the frame). The pads that prevent it from sliding across my counter in big waves (we live and travel on a boat) are secured around the steel legs as opposed to just being glued onto the bottom (like the pads of my previous organizer were, which fell off). There is no metal hanging over onto the sink edge to cause rust (like the metal that had caused rust with my old organizer.) The dish-brush holder can fit on the inside of the frame or it can hang on the outside of the organizer, which is nice because it makes more room if you have many tools that you like to use at the sink. And it can be compact if you don't. Be cautious not to remove the hanging part (dish-brush holder) too often because repeated wear can cause the paint to rub off and it could begin to rust. The "Water Absorbent Diatomite Stone" is new to me but it seems to be working just fine. I assume I will have to clean out the ridges of it as gunk forms there, but that would be the case with any sink organizer tray. I am very satisfied with this organizer, it is robust and it solves all the problems I had with my previous one. The price is on the higher side of similar organizers, currently priced at $23.99. All the best, Mrs. dr
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 16, 2025
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Orlando J.
Dallas, US
★★★★★ 5
Great design for a kitchen sink organizer -- will not tip or accumulate water
We've had an Oxo kitchen sink organizer for years, and it's been fine, except 1) tall brushes (for example, Oxo brushes) make it tippy, stray elbows or imperfect placement of the brush would knock it into the sink and 2) it built up a soapy sludge in the bottom that that had to be drained and wiped down constantly. This item solves both issues perfectly. Likes: Size - I think it's about 5 inches deep, which is just right to fit the strip of countertop that runs behind the sink, up against the backsplash Weight - The drying stone in the bottom gives the baskets some real heft, so there is no tipping it over by bumping a brush handle -- it really stays put Drying stone -- The diatomaceous drying stone that slides into the bottom of the main basket is a great idea. These are porous stones that will absorb water and then allow it to evaporate fairly quickly. So far, it seems to be doing its job well. I'm sure the stone will need a wipe down now and then to stay clean, but no puddles of sludgy soapy water in the bottom is a big plus Overall Design/Build quality -- The unit seems solid. It's a simple design, but there are no sharp edges or unfinished bits. Once in place it doesn't wobble a bit. I wasn't sure about the black powder-coated finish, but installed it looks clean and it's unobtrusive. I appreciate that the smaller basket for tall brushes sits on hooks and can be hung inside or outside the main basket. Ours sits inside, but there's plenty of room left over for sponges . And there's still room to stand up a bottle of liquid detergent or counter-top spray. NOT SO LIKES Nothing so far. I notice a lot of this style of sink organizer on Amazon, so presumably they're selling well. It's a great improvement over the older kinds. Five big, clean, well-organized stars. Highly recommended.
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Reviewed in the United States on December 6, 2025
T
Verified Purchase
the_Mrs.C
Cuba, US
★★★★★ 5
Love it!
This fits on my counter perfectly! It’s built well and hold so much things!
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Reviewed in the United States on March 27, 2026
A
Verified Purchase
Amazon Customer
Carnegie, US
★★★★★ 5
Works well
Works well
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Reviewed in the United States on March 8, 2026
F
Verified Purchase
froggydog2
Birmingham, US
★★★★★ 5
Great looking sink organizer.
Works perfectly on the edge of my sink. Holds everything I need to contain for using in and around sink area. Nice looking and very functional A+++++++++
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Reviewed in the United States on December 13, 2025

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