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Description
DUSP6 His Tag Protein, HumanProduct Specification Species Human Synonyms Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen activated protein kinase phosphatase 3 (MAP kinase phosphatase 3; MKP 3) Accession Q16828 Amino Acid Sequence Met1 Thr381, with N terminal His Expression System E. coli Molecular Weight 43kDa Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage
Product Specification
| Species | Human |
| Synonyms | Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3 (MAP kinase phosphatase 3; MKP-3) |
| Accession | Q16828 |
| Amino Acid Sequence | Met1-Thr381, with N-terminal His |
| Expression System | E.coli |
| Molecular Weight | 43kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 2mM TCEP, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Nat Commun. 2022 Nov 5;13(1):6672. |
Background
Dual-specific phosphatase-6 (DUSP6), also known as mitogen-activated protein kinase phosphatase-3 (MKP3), has been characterized as a negative feedback regulator of ERK1/2 signaling. It serves a specific and conserved function on the dephosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2). DUSP6 is a cytoplasmic DUSP known to catalyze the removal of phosphate groups from threonine and tyrosine residues on Erk1/2, Which belongs to a family of 25 protein phosphatases that dephosphorylate phosphotyrosine and phosphoserine/phosphothreonine residues within the same substrate.
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4.8 ★★★★★
Based on 1715 reviews
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Product Reviews
★★★★★ 5
Good size for my pug!
Color: Dentachew 3 Pk
I love how it’s a good size for my pug it is easy for her to play around with. I had stuffed animals for her to play around with but it looked so silly to watch her play with something that is 10 times as big as her 😂. I had to buy her these toys and she seemed so happy when she first got them.
It was so funny and interesting that she had to chew all three toys and decide which one she liked. At first she decided to play with the rope toy and she liked the rope toy, then she got curious with the rubber toys. She has decided that the rubber toys are her favorite and I’ve tried to engage with playing with her with the rope toy. She gets more interactive with the rubber toys! She also looked so relieved while chewing them so that’s a plus!
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Reviewed in the United States on May 16, 2026
★★★★★ 4
Good for Teething puppies
Color: Teething Stick
After getting my fingers chewed and bitten by my new foster - 8 week old Yorkie , I was desperate to find good teething toys. Fortunately this one arrived quickly. Turned out to be very good for teething puppies! Charlie loves this cooling stick. Once it’s frozen, the cold really seems to soothe his sore gums. The icy part doesn’t stay frozen for long, but it works so well that I bought a second one to keep ready in the freezer while he’s working on the first.
Even after it warmed up, he still enjoyed chewing on the soft stuffed part and the tentacles. The product card says not to use it as a chew toy, so supervision is a must, but it held up just fine so far.
Overall, this has been a big help during the teething phase — short-lived when frozen, but very effective while it lasts! And worth every penny to save my fingers from being a chew toy.
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Reviewed in the United States on October 7, 2025
★★★★★ 5
From Puppy Teething to Adult Favorite – 7 Years Later
Color: Teething Stick, Color: Teething Stick
This has been one of the best toys I’ve ever bought! My dog has loved the Pupstages Cool Teething Stick since she was a tiny puppy, and now at 7 years old, it’s still one of her absolute favorites. It’s been amazing for soothing teething when she was little, and now she still enjoys chewing on it and carrying it around.
It’s held up surprisingly well over the years, especially considering how much use it’s gotten. I also love that you can cool it for extra relief—it really helped during those puppy stages.
If you’re looking for a toy that lasts and actually becomes a long-term favorite, this is definitely it. Highly recommend for both puppies and even older dogs who still love a good chew! 🐶
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Reviewed in the United States on May 1, 2026
★★★★★ 5
Great for little dogs that like to chew
Color: Hedgehog
Great for my 10 lb chihuahua that loves to chew! Keeps his teeth clean!
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Reviewed in the United States on June 7, 2026
★★★★★ 5
Cute Fun Puppies Love it Immediately Good Price
Color: Teething Stick
This little top was a huge success for my active Multipoo! She started playing with it immediately. I think it will become her favorite toy! It isn't expensive. It is well made and very cute!
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Reviewed in the United States on June 7, 2026
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